New PDF release: ABC Transporters and Multidrug Resistance (Wiley Series in

By Ahcene Boumendjel, Jean Boutonnat, Jacques Robert

ISBN-10: 0470227346

ISBN-13: 9780470227343

A entire evaluation of the most up-tp-date clinical learn on ABC transporters and multidrug resistanceATP-binding cassette transporter genes (ABC transporters) are identified to play an important function within the improvement of multidrug resistance (MDR). MDR is the power of pathologic cells, similar to tumors, to resist chemical substances designed to focus on and wreck such cells. In MDR, sufferers who're on medicine finally advance resistance not to basically the drug they're taking, yet to numerous types of drugs.ABC Transporters and Multidrug Resistance bargains a vital source for pharmaceutical researchers who're operating to find medicines to counteract multidrug resistance in illnesses similar to melanoma. in a single accomplished quantity, this publication encompasses a choice of the most up-tp-date wisdom at the involvement of ABC transporters in drug shipping and resistance.This finished quantity offers an outline at the description of the constitution, the genome, general tissue expression, physiological point, and mechanism of motion of the ABC protein. The specialist individuals discover the expression, detection, and implications of ABC proteins in hematological malignancies and strong tumors and ABC proteins and pathogenic microorganisms. This quantity additionally explains MDR modulation via inhibition of ABC transporters and the layout of inhibitors and mechanism of motion. additionally, the ebook bargains crucial info at the organic and medical element of multidrug resistance.

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Extra resources for ABC Transporters and Multidrug Resistance (Wiley Series in Drug Discovery and Development)

Example text

Vesicle formation displays biphasic kinetics, with an initial rapid increase followed by a plateau where no further increase is observed. It has been suggested that a pH shift in various cytoplasmic organelles might contribute to this intracellular redistribution of anticancer drugs (122). Owing to their positive electric charge at physiologic pH, most anticancer drugs (vinca alkaloids, anthracyclines) are accumulated under their protonated form on the side of a membrane at which the pH is lower.

In neuroblastoma, a childhood cancer, the overexpression of the neuronal variant N-myc (MYCN) enhances ABCB1 gene expression and constitutes a marker for poor prognosis 22 THE P-GLYCOPROTEIN 170 (41). Indeed, N-myc overexpression is frequently associated with the MDR phenotype and high expression of ABCB1 in neuroblastoma metastasic tumors. Epigenetic changes in histone H3 methylation induced by cytotoxic drug treatments have been shown to be responsible for the ABCB1 gene overexpression in cancer-resistant cells (42).

The transmembrane α-helices are connected by extracellular or cytosolic loops, followed by a large cytosolic domain containing an ATPbinding site (65) or NBD (NBD1 and NBD2 for the first and the second half, respectively). Each NBD contains nucleotide-binding motifs, including Walker A (P-loop) and Walker B sequences, and the ABC signature motif (LSGGQ). A central sequence connects the two homologous halves of the protein and is called the “linker” region. The two halves share 43% sequence identity and 78% similarity, and TMDs of these proteins display β-sheets rather than αhelices.

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ABC Transporters and Multidrug Resistance (Wiley Series in Drug Discovery and Development) by Ahcene Boumendjel, Jean Boutonnat, Jacques Robert


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